Pharmacogenomics of GPCR genes in type 2 diabetes and obesity

G protein–coupled receptors (GPCRs) are important drug targets in type 2 diabetes (T2D). GPCR gene variants can modify the responsiveness to drugs and be a risk factor for T2D development associated traits. genes of interest this respect GIPR, GLP1R, MC4R, MTNR1B. Once association with or altered response established, consequences on receptor function have determined. Depending nature function, different types compounds proposed re-establishing normal providing eventually genotype-based personalized therapy carriers variants.